Neuropathic Pain

CNS|CRO`s rodent models of neuropathic pain provide a sensitive method for testing therapeutants aimed at modulating pain pathways.

The spared nerve injury (SNI) paradigm model allows for repeated testing as well as assessment of efficacy at various time points post-treatment. Test article administration may be performed via intraplantar injection, topical, gavage, or intra-nasal application.

Chronic constriction injury (CCI) is a rodent model of neuropathic pain as a consequence of sciatic nerve damage. The model is induced through constriction of the sciatic nerve with chromic gut sutures, which causes inflammation of the nerve for several weeks. This model allows testing of lead compounds for the treatment of chronic neuropathic pain, with a particular focus on inflammatory processes.

Printable Model Information Sheets
Chronic Constriction Model – Information Sheet
Spared Nerve Model – Information Sheet

Please contact info@cnscro.com for further details.